Sequential tests for gene-environment interactions in matched case-control studies
نویسندگان
چکیده
منابع مشابه
Flexible matching in case-control studies of gene-environment interactions.
Because of the lack of power of case-control study designs to detect gene-environment interactions, flexible matching has recently been proposed as a method of improving efficiency. In this paper, the authors consider a large-sample approximation method that allows estimation of the most efficient matching strategy when genotype and exposure are either independent or associated. The authors pro...
متن کاملUsing imputed genotype data in the joint score tests for genetic association and gene-environment interactions in case-control studies.
Genome-wide association studies (GWAS) are now routinely imputed for untyped single nucleotide polymorphisms (SNPs) based on various powerful statistical algorithms for imputation trained on reference datasets. The use of predicted allele counts for imputed SNPs as the dosage variable is known to produce valid score test for genetic association. In this paper, we investigate how to best handle ...
متن کاملMatched Case-Control Studies
'National Cancer Institute, Biometric Research Branch, DCTD, Executive Plaza North, Room 739, 6130 Executive Boulevard, MSC 7434, Bethesda, Maryland 20892-7434, U.S.A. 2National Cancer Institute, Biometry Research Group, DCP, Executive Plaza North, Room 344, 6130 Executive Boulevard, Bethesda, Maryland 20892, U.S.A. 3F0x Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 1911...
متن کاملAdaptive tests for detecting gene-gene and gene-environment interactions.
There has been an increasing interest in detecting gene-gene and gene-environment interactions in genetic association studies. A major statistical challenge is how to deal with a large number of parameters measuring possible interaction effects, which leads to reduced power of any statistical test due to a large number of degrees of freedom or high cost of adjustment for multiple testing. Hence...
متن کاملBayesian Inference for Matched Case-Control Studies
Case-control studies occupy a central place in epidemiological research. The basic idea here is the comparison of a group (the “cases”) having the outcome of interest (normally some disease) with respect to a control group (those without disease) regarding one or more characteristics (exposure to certain external events). One of the early examples, which sparked a lot of debate in the fifties b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2004
ISSN: 0277-6715,1097-0258
DOI: 10.1002/sim.2071